Ether hydrochloride → HCID 57411377, compound

HRID 333998Notes

Reaction equation

HRID 333998 reaction equation
[CH2:1]([NH:8][CH2:9][C@H:10]([NH:12][S:13]([C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[CH:22]=[N:21][CH:20]=[CH:19]2)(=[O:15])=[O:14])[CH3:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:26].C(OCC)C>ClCCl>[ClH:26].[ClH:26].[CH2:1]([NH:8][CH2:9][C@H:10]([NH:12][S:13]([C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[CH:22]=[N:21][CH:20]=[CH:19]2)(=[O:15])=[O:14])[CH3:11])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 57411378HCID 57411378, compound

Product 1

HCID 57411377HCID 57411377, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

368 mg of (R)—N-{1-(benzylamino)propan-2-yl}isoquinoline-6-sulfonamide was dissolved in 2 mL of dichloromethane. To the solution, 3 mL of a 1 M hydrochloric acid-diethyl ether solution was added, and the mixture was stirred at room temperature for 4 hours. The deposited crystal was collected using a Kiriyama funnel and dried under reduced pressure at 60° C. to obtain 360 mg of the title compound as a white solid (84%).

Workup

  1. customThe deposited crystal was collected
  2. customdried under reduced pressure at 60° C.

Sources & evidence

ORD record
ord-25cc6ccd88db4042a15fbea02b8b556d
Source dataset
uspto-grants-2014_11
Patent number
US08883792B2

Reaction notes

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