3-Fluoro-4-methylbenzeneboronic acid → 1-(3-Fluoro-4-methyl-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid

HRID 334013Notes

Reaction equation

HRID 334013 reaction equation
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[CH:6][C:7]=1[CH3:8].[NH:12]1[CH:16]=[N:15][C:14]([C:17]([O:19]C)=[O:18])=[N:13]1.ClC1C=C(N2C=NC(C(O)=O)=N2)C=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([N:12]2[CH:16]=[N:15][C:14]([C:17]([OH:19])=[O:18])=[N:13]2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

4

Reactant 3

HCID 27826743-Fluoro-4-methylbenzeneboronic acidHCID 713019271-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acidHCID 178499122HCID 178499122, compound

Product 1

HCID 866882401-(3-Fluoro-4-methyl-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid

Procedure

This intermediate was prepared from 3-fluoro-4-methylphenylboronic acid and methyl 1,2,4-triazole-3-carboxylate in two steps according to the preparation of 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid.

Sources & evidence

ORD record
ord-83edebd079c2490eb9b7fe792c23ccf2
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

Loading…