反应详情

A mixture of 23.0 g (66.1 mmol) 2,2-dimethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester in 200 mL DCM was treated with 34.5 mL (448 mmol) TFA. The reaction mixture was stirred at RT over night and concentrated in vacuo. The residue was triturated with diethyl ether. The solid was filtered, washed with diethyl ether and dried.

1. concentrationconcentrated in vacuo
2. customThe residue was triturated with diethyl ether
3. filtrationThe solid was filtered
4. washwashed with diethyl ether
5. customdried