Trifluoroacetic acid → HCID 86688245, compound

HRID 334018Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH:22]3[CH2:24][CH2:23]3)[N:17]=2)=[O:15])[CH2:10][C:9]1([CH3:26])[CH3:25])=O)(C)(C)C.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>>[F:30][C:29]([F:32])([F:31])[C:27]([OH:33])=[O:28].[CH:22]1([C:18]2[N:17]=[C:16]([C:14]([N:11]3[CH2:12][CH2:13][NH:8][C:9]([CH3:26])([CH3:25])[CH2:10]3)=[O:15])[CH:21]=[CH:20][CH:19]=2)[CH2:23][CH2:24]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86688247HCID 86688247, compound

Product 1

HCID 86688245HCID 86688245, compound

Procedure

To a mixture of 190 mg (0.529 mmol) 4-(6-cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester was added 500 μl (6.48 mmol) TFA. The resulting mixture was stirred at RT for 3.5 h. The solvent was evaporated.

Workup

customThe solvent was evaporated

Sources & evidence

ORD record: ord-4abe2bebf6be4d1191637517c398a0b3
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883789B2

Reaction notes

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