Trifluoroacetic acid → HCID 86688248, compound

HRID 334019Notes

Reaction equation

HRID 334019 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH:22]([CH3:24])[CH3:23])[N:17]=2)=[O:15])[CH2:10][C:9]1([CH3:26])[CH3:25])=O)(C)(C)C.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>>[F:30][C:29]([F:32])([F:31])[C:27]([OH:33])=[O:28].[CH3:25][C:9]1([CH3:26])[NH:8][CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH:22]([CH3:23])[CH3:24])[N:17]=2)=[O:15])[CH2:10]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 866882504-(6-Isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 86688248HCID 86688248, compound

Procedure

To a mixture of 55.0 mg (0.152 mmol) 4-(6-isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester was added 100 μl (1.30 mmol) TFA. The resulting mixture was stirred at RT for 12 h. The solvent was evaporated.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-bf0682560fc846aca06af085310abfc4
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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