Diisopropylethylamine → HCID 86688251, compound
Reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([C:9]([OH:11])=O)[CH:6]=[CH:5][CH:4]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C.FC(F)(F)C(O)=O.[CH2:50]([O:57][C:58]([N:60]1[CH2:65][CH2:64][NH:63][CH2:62][C:61]1([CH3:67])[CH3:66])=[O:59])[C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1>C(Cl)Cl>[CH2:50]([O:57][C:58]([N:60]1[CH2:65][CH2:64][N:63]([C:9]([C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[N:8]=2)=[O:11])[CH2:62][C:61]1([CH3:67])[CH3:66])=[O:59])[C:51]1[CH:52]=[CH:53][CH:54]=[CH:55][CH:56]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
510 mg (3.31 mmol) 6-methoxy-2-pyridinecarboxylic acid was stirred with 1.17 g (3.31 mmol) TBTU and 1.50 mL (8.72 mmol) DIPEA in 10 mL DCM at RT. After 10 min, 1.20 g (3.31 mmol) 2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester trifluoroacetate was added and the reaction mixture was stirred at RT for 2 h. Then the reaction mixture was washed with saturated aqueous NaHCO3 solution. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by flash chromatography (PE/EtOAc=9/1→1/2).
Workup
- washThen the reaction mixture was washed with saturated aqueous NaHCO3 solution
- dry with materialThe combined organic phases were dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe crude material was purified by flash chromatography (PE/EtOAc=9/1→1/2)
Sources & evidence
- ORD record
- ord-4da99b73ff814972b94d4414e9eb1435
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08883789B2
Reaction notes
Loading…