HCID 86688251, compound → (3,3-Dimethyl-1-piperazinyl)(6-methoxy-2-pyridinyl)methanone

HRID 334021Notes

Reaction equation

HRID 334021 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[N:20]=2)=[O:18])[CH2:13][C:12]1([CH3:28])[CH3:27])=O)C1C=CC=CC=1>[Pd].CO>[CH3:27][C:12]1([CH3:28])[NH:11][CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[N:20]=2)=[O:18])[CH2:13]1

Participants

4

Reactant 1

HCID 86688251HCID 86688251, compound

Product 1

HCID 86688252(3,3-Dimethyl-1-piperazinyl)(6-methoxy-2-pyridinyl)methanone

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 1.10 g (2.87 mmol) 4-(6-methoxy-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester and 100 mg palladium on carbon in 20 mL methanol was hydrogenated at RT for 12 h at 3 bar. The catalyst was removed by filtration and the solvent was evaporated in vacuo.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-a19f4a0946e746b6bbd57e8f9b6473e4
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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