反应详情

45.0 mL (60.2 mmol) aqueous ammonia solution (25%) was added over 20 minutes to a solution of 15.0 g (57.4 mmol) ethyl 2-chloro-2-(2-(3-chlorophenyl)hydrazono)acetate in 75 mL THF and stirred for 1 h. The resulting mixture was diluted and extracted with hexane and EtOAc (1:1 mixture). The organic layer was washed with brine, dried over sodium sulfate, filtered, concentrated and used without further purification for the next synthesis step (yield: 12.0 g (92%)).

1. additionThe resulting mixture was diluted
2. extractionextracted with hexane and EtOAc (1:1 mixture)
3. washThe organic layer was washed with brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated
7. customused without further purification for the next synthesis step (yield: 12.0 g (92%))