HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(3-Chloro-phenyl)-2H-tetrazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 2H-Tetrazole-5-carboxylic acid, 2-(3-chlorophenyl)-, ethyl ester | HCID 574534 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(3-Chloro-phenyl)-2H-tetrazole-5-carboxylic acid | HCID 66490976 | — |
Reaction Steps
7.00 g (27.7 mmol) 2-(3-chloro-phenyl)-2H-tetrazole-5-carboxylic acid ethyl ester was dissolved in 50 mL THF and 50 mL water and treated with 2.33 g (55.4 mmol) LiOH at RT for 14 h. The reaction mixture was concentrated and acidified with 1 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883789B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-411eb9e1998e45fa822c29f3798f8244 |
| Source note | uspto-grants-2014_11 |