Water → 2-(3-Chloro-phenyl)-2H-tetrazole-5-carboxylic acid

HRID 334029Notes

Reaction equation

HRID 334029 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[N:8][N:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[N:10]=1)=[O:5])C.O.[Li+].[OH-]>C1COCC1>[Cl:17][C:13]1[CH:12]=[C:11]([N:9]2[N:8]=[N:7][C:6]([C:4]([OH:5])=[O:3])=[N:10]2)[CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 5745342H-Tetrazole-5-carboxylic acid, 2-(3-chlorophenyl)-, ethyl ester

Product 1

HCID 664909762-(3-Chloro-phenyl)-2H-tetrazole-5-carboxylic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7.00 g (27.7 mmol) 2-(3-chloro-phenyl)-2H-tetrazole-5-carboxylic acid ethyl ester was dissolved in 50 mL THF and 50 mL water and treated with 2.33 g (55.4 mmol) LiOH at RT for 14 h. The reaction mixture was concentrated and acidified with 1 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and dried.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-411eb9e1998e45fa822c29f3798f8244
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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