Trifluoroacetic acid → (2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]triazol-3-yl)-methanone trifluoroacetate

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Reaction Steps

To a stirred solution of 4.10 g (10.6 mmol) 3,3-dimethyl-4-(1-phenyl-1H-[1,2,4]-triazole-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester in 20 mL DCM was added 7.00 mL (90.7 mmol) TFA and the resulting mixture was stirred at RT for 4 h. The solvent was evaporated. The residue was triturated with diethyl ether and DCM. The precipitate was filtered off, washed with diethyl ether and dried.

Provenance & Evidence