Trifluoroacetic acid → (2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]triazol-3-yl)-methanone trifluoroacetate

HRID 334035Notes

Reaction equation

HRID 334035 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[N:20]=[CH:19][N:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:17]=2)=[O:15])[C:10]([CH3:28])([CH3:27])[CH2:9]1)=O)(C)(C)C.[C:29]([OH:35])([C:31]([F:34])([F:33])[F:32])=[O:30]>C(Cl)Cl>[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[CH3:27][C:10]1([CH3:28])[CH2:9][NH:8][CH2:13][CH2:12][N:11]1[C:14]([C:16]1[N:20]=[CH:19][N:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:17]=1)=[O:15]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 866882583,3-Dimethyl-4-(1-phenyl-1H-[1,2,4]triazole-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 86688259(2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]triazol-3-yl)-methanone trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 4.10 g (10.6 mmol) 3,3-dimethyl-4-(1-phenyl-1H-[1,2,4]-triazole-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester in 20 mL DCM was added 7.00 mL (90.7 mmol) TFA and the resulting mixture was stirred at RT for 4 h. The solvent was evaporated. The residue was triturated with diethyl ether and DCM. The precipitate was filtered off, washed with diethyl ether and dried.

Workup

  1. customThe solvent was evaporated
  2. customThe residue was triturated with diethyl ether and DCM
  3. filtrationThe precipitate was filtered off
  4. washwashed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-8128f9b912dc49acb2fbe4c195d44e6c
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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