1-Boc-3,3-dimethylpiperazine → (2,2-Dimethyl-piperazin-1-yl)-[2-(3-fluoro-phenyl)-2H-tetrazol-5-yl]-methanone trifluoroacetate

HRID 334041Notes

Reaction equation

HRID 334041 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([C:13]([OH:15])=O)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.C(OC([N:23]1[CH2:28][CH2:27][NH:26][C:25]([CH3:30])([CH3:29])[CH2:24]1)=O)(C)(C)C.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].CC1(C)CNCCN1C(C1N=CN(C2C=CC=CC=2)N=1)=O>>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[CH3:29][C:25]1([CH3:30])[CH2:24][NH:23][CH2:28][CH2:27][N:26]1[C:13]([C:10]1[N:11]=[N:12][N:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=2)[N:9]=1)=[O:15]

Participants

4

Reactant 3

HCID 227103871-Boc-3,3-dimethylpiperazineHCID 822836232-(3-Fluoro-phenyl)-2H-tetrazole-5-carboxylic acidHCID 86688259(2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]triazol-3-yl)-methanone trifluoroacetate

Product 1

HCID 86688271(2,2-Dimethyl-piperazin-1-yl)-[2-(3-fluoro-phenyl)-2H-tetrazol-5-yl]-methanone trifluoroacetate

Procedure

This intermediate was prepared from 2-(3-fluoro-phenyl)-2H-tetrazole-5-carboxylic acid and 3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester in two steps according to the preparation of (2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate.

Sources & evidence

ORD record
ord-d4b2b1c2b674483c8b66726bc1033d2f
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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