Methanol → 2-Chloro-6-methoxypyridin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	4-Amino-2,6-dichloropyridine	HCID 137652	—
Reactant	Sodium	HCID 5360545	—
Product	2-Chloro-6-methoxypyridin-4-amine	HCID 71302512	—

Reaction Conditions

Temperature	150 °C

Reaction Steps

To a solution of 1.84 g (44.0 mmol) sodium in 40 mL MeOH was added 6.72 g (40.0 mmol) 2,6-dichloro-pyridin-4-ylamine. The reaction mixture was stirred at 150° C. for 30 min under microwave irradiation. The solvent was evaporated and ice water was added. The precipitate was filtered off, washed with water and dried.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08883789B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-d4a7b52437e44155b9cd4be82e8585e1
Source note	uspto-grants-2014_11