Sodium Hydroxide → HCID 84696473, compound

HRID 334059Notes

Reaction equation

HRID 334059 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[C:7]([O:17][CH3:18])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH3:16])=[CH:10][CH:9]=2)=[O:4].[OH-].[Na+]>CO>[CH3:18][O:17][C:7]1[C:8]2[C:13](=[CH:12][C:11]([O:15][CH3:16])=[CH:10][CH:9]=2)[CH:14]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 866882833-Isoquinolinecarboxylic acid, 1,6-dimethoxy-, methyl ester

Product 1

HCID 84696473HCID 84696473, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

500 mg (2.02 mmol) 1,6-dimethoxy-isoquinoline-3-carboxylic acid methyl ester was dissolved in 20 mL MeOH and treated with 2.50 mL 4 M aqueous NaOH solution at RT for 12 h. The solvent was removed by distillation, the residue taken up in water and acidified with 4 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and purified by HPLC.

Workup

  1. customThe solvent was removed by distillation
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. custompurified by HPLC

Sources & evidence

ORD record
ord-9c1a3869d16e4b3b965d2666b7d5a2aa
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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