HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Bromo-methyl-benzofuran-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 5-Bromo-2-methyl-benzofuran-3-carboxylic acid methyl ester | HCID 86688289 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Bromo-methyl-benzofuran-3-carboxylic acid | HCID 86688290 | — |
Reaction Steps
350 mg (1.30 mmol) 5-bromo-2-methyl-benzofuran-3-carboxylic acid methyl ester was dissolved in 10 mL THF and treated with 5.0 mL 1 M aqueous LiOH solution at 60° C. for 12 h. The reaction mixture was acidified with 1 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883789B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-721f72cc2ab345f18d94b62a8a11d0e1 |
| Source note | uspto-grants-2014_11 |