Hydrochloric Acid → 5-Bromo-methyl-benzofuran-3-carboxylic acid

HRID 334067Notes

Reaction equation

HRID 334067 reaction equation
C[O:2][C:3]([C:5]1[C:9]2[CH:10]=[C:11]([Br:14])[CH:12]=[CH:13][C:8]=2[O:7][C:6]=1[CH3:15])=[O:4].[Li+].[OH-].Cl>C1COCC1>[Br:14][C:11]1[CH:12]=[CH:13][C:8]2[O:7][C:6]([CH3:15])=[C:5]([C:3]([OH:4])=[O:2])[C:9]=2[CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 866882895-Bromo-2-methyl-benzofuran-3-carboxylic acid methyl ester

Product 1

HCID 866882905-Bromo-methyl-benzofuran-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

350 mg (1.30 mmol) 5-bromo-2-methyl-benzofuran-3-carboxylic acid methyl ester was dissolved in 10 mL THF and treated with 5.0 mL 1 M aqueous LiOH solution at 60° C. for 12 h. The reaction mixture was acidified with 1 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and dried.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-721f72cc2ab345f18d94b62a8a11d0e1
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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