反应详情

温度

140 °C

A mixture of 500 mg (0.10 mmol) [4-(6-bromo-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-chloro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone, 28 mg (0.13 mmol) 3,6-dihydro-2H-pyran-4-boronic acid pinacol ester, 16 mg (0.020 mmol) [1,1′-bis(diphenylphosphino)-ferrocene]dichloropalladium(II) complex with DCM (1:1) and 0.10 mL 5M aqueous potassium carbonate solution in 1.0 mL dioxane and 0.50 mL MeOH was stirred at 140° C. for 15 min under microwave irradiation. The reaction mixture was filtered through Alox (alkaline) and purified by HPLC.

1. filtrationThe reaction mixture was filtered through Alox (alkaline)
2. custompurified by HPLC