Trifluoroacetic acid → HCID 86688302, compound

HRID 334080Notes

Reaction equation

HRID 334080 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[N:17]=2)=[O:15])[C:10]([CH3:25])([CH3:24])[CH2:9]1)=O)(C)(C)C.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]>C(Cl)Cl>[F:29][C:28]([F:31])([F:30])[C:26]([OH:32])=[O:27].[CH3:24][C:10]1([CH3:25])[CH2:9][NH:8][CH2:13][CH2:12][N:11]1[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[N:17]=1)=[O:15]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 866883014-(6-Methoxy-pyridine-2-carbonyl)-3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 86688302HCID 86688302, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 780 mg (2.23 mmol) 4-(6-methoxy-pyridine-2-carbonyl)-3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester and 2.00 mL (25.9 mmol) TFA in 10 mL DCM was stirred at RT for 12 h. The solvent was evaporated and the residue triturated with diethyl ether. The precipitate was filtered off, washed with diethyl ether and dried.

Workup

  1. customThe solvent was evaporated
  2. customthe residue triturated with diethyl ether
  3. filtrationThe precipitate was filtered off
  4. washwashed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-ffad4ae34e014e64ad2ebe2963384d30
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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