反应详情

A mixture of 780 mg (2.23 mmol) 4-(6-methoxy-pyridine-2-carbonyl)-3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester and 2.00 mL (25.9 mmol) TFA in 10 mL DCM was stirred at RT for 12 h. The solvent was evaporated and the residue triturated with diethyl ether. The precipitate was filtered off, washed with diethyl ether and dried.

1. customThe solvent was evaporated
2. customthe residue triturated with diethyl ether
3. filtrationThe precipitate was filtered off
4. washwashed with diethyl ether
5. customdried