反应详情

A mixture of 130 mg (0.524 mmol) 4-benzyl-5-methoxymethyl-5-methyl-piperazin-2-one in 5 mL THF was cooled with ice and 780 μL (0.780 mmol) 1M lithium aluminum hydride solution in THF was added dropwise under argon atmosphere. The resultant mixture was stirred 3 h under ice-bath cooling and 2.5 h at Rt. Then the mixture was quenched with saturated aqueous Na2SO4 solution, stirred for 1 h, filtered through Celite, washed with EtOAc and concentrated in vacuo.

1. additionwas added dropwise under argon atmosphere
2. temperaturecooling and 2.5 h at Rt
3. customThen the mixture was quenched with saturated aqueous Na2SO4 solution
4. filtrationfiltered through Celite
5. washwashed with EtOAc
6. concentrationconcentrated in vacuo