HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-(3-(fluoro-phenyl)-1H-[1,2,4]-triazol-3-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-(3-fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid | HCID 86688238 | — |
| Reactant | (4,5-Dibromo-furan-2-yl)-(2-ethyl-piperazin-1-yl)-methanone | HCID 86688319 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3-(fluoro-phenyl)-1H-[1,2,4]-triazol-3-yl]-methanone | HCID 86688318 | — |
Reaction Steps
50 mg (0.24 mmol) 1-(3-fluoro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid was stirred with 85 mg (0.27 mmol) TBTU and 0.10 mL (0.57 mmol) DIPEA in 1.5 mL DMF at RT. After 10 min, 89 mg (0.24 mmol) (4,5-dibromo-furan-2-yl)-(2-ethyl-piperazin-1-yl)-methanone was added and the mixture was stirred at RT for 12 h. The reaction mixture was purified by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883789B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-86d122a2b92c412aa3fa4694e3e733e9 |
| Source note | uspto-grants-2014_11 |