反应详情

50 mg (0.24 mmol) 1-(3-fluoro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid was stirred with 85 mg (0.27 mmol) TBTU and 0.10 mL (0.57 mmol) DIPEA in 1.5 mL DMF at RT. After 10 min, 89 mg (0.24 mmol) (4,5-dibromo-furan-2-yl)-(2-ethyl-piperazin-1-yl)-methanone was added and the mixture was stirred at RT for 12 h. The reaction mixture was purified by HPLC.

1. customThe reaction mixture was purified by HPLC