反应详情

HCl (5 mL, 5 mmol, 1 M aqueous solution) was added to a solution of 2-[2,6-dichloro-9-(tetrahydro-pyran-2-yl)-9H-purin-8-yl]-propan-2-ol (6.0 g, 20.66 mmol) in a mixture of DCM (15 mL) and methanol (15 mL) and the resulting solution stirred at RT for 1 h, then concentrated in vacuo. The resulting residue was purified by column chromatography (SiO2, gradient 0 to 50% methanol in DCM) affording 2-(2,6-Dichloro-9H-purin-8-yl)-propan-2-ol as a dark solid (3.38 g, 66%). LCMS (method A): RT=2.12 min, [M−H]=245/247. 1H NMR (400 MHz, CDCl3): δ 1.50 (6H, s)

1. concentrationconcentrated in vacuo
2. customThe resulting residue was purified by column chromatography (SiO2, gradient 0 to 50% methanol in DCM)