1-(2-Methoxyphenyl)piperazine → HCID 71602692, compound

HRID 334289Notes

Reaction equation

HRID 334289 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]1[C:24]([CH:29]=O)=[CH:25][CH:26]=[CH:27][CH:28]=1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+].C1(C2C=CC=CC=2)C=CC=CC=1CN1CCN(C2C=CC=CC=2)CC1>>[CH3:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH2:29][N:12]1[CH2:13][CH2:14][N:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[CH2:10][CH2:11]1

Participants

5

Reactant 4

HCID 13461-(2-Methoxyphenyl)piperazineHCID 6025282'-Methoxy[biphenyl]-2-carbaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 716025231-(Biphenyl-2-ylmethyl)-4-phenylpiperazine

Product 1

HCID 71602692HCID 71602692, compound

Procedure

382 mg of the target compound (0.98 mmol, 59.6%) was obtained using 1-(2-methoxyphenyl)piperazine (634 mg, 3.30 mmol), 2′-methoxybiphenyl-2-carbaldehyde (350 mg, 1.65 mmol) and NaBH(OAc)3 (1.1 g, 4.95 mmol) according to the synthesis method of Compound 1.

Sources & evidence

ORD record
ord-0c8cc24a87dc473a90786ef98c2e6fb5
Source dataset
uspto-grants-2014_11
Patent number
US08883796B2

Reaction notes

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