2-Bromopyridine → HCID 66597894, compound

HRID 334642Notes

Reaction equation

HRID 334642 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([OH:14])[CH2:9][CH2:10][CH2:11][C:12]#[CH:13]>>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:13]#[C:12][CH2:11][CH2:10][CH2:9][CH2:8][OH:14]

Participants

3

Reactant 2

HCID 79732-BromopyridineHCID 702345-Hexyn-1-ol

Product 1

HCID 66597894HCID 66597894, compoundYield 78%

Procedure

The title compound was prepared in accordance with the general method of Example 1, from 2-bromopyridine (6.44 g, 40.8 mmol) and hex-5-yn-1-ol (4.00 g, 40.8 mmol). The crude residue was purified by flash chromatography (DCM/MeOH 1:1) to yield 5.56 g (31.7 mmol, 78%) of 6-pyridin-2-yl-hex-5-yn-1-ol as an orange oil.

Workup

  1. customThe crude residue was purified by flash chromatography (DCM/MeOH 1:1)

Sources & evidence

ORD record
ord-bb67b104fb6749668ec7241f42968218
Source dataset
uspto-grants-2014_11
Patent number
US08883826B2

Reaction notes

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