1-(Trimethylsilyl)prop-1-yne → HCID 66598426, compound

HRID 334729Notes

Reaction equation

HRID 334729 reaction equation
Cl[CH2:2][C:3]1[N:7]([CH3:8])[C:6]2[CH:9]=[C:10]([F:14])[CH:11]=[C:12]([F:13])[C:5]=2[N:4]=1.[CH3:15][Si:16]([CH3:21])([CH3:20])[C:17]#[C:18][CH3:19]>>[F:13][C:12]1[C:5]2[N:4]=[C:3]([CH2:2][CH2:19][C:18]#[C:17][Si:16]([CH3:21])([CH3:20])[CH3:15])[N:7]([CH3:8])[C:6]=2[CH:9]=[C:10]([F:14])[CH:11]=1

Participants

3

Reactant 2

HCID 803631-(Trimethylsilyl)prop-1-yneHCID 66598007HCID 66598007, compound

Product 1

HCID 66598426HCID 66598426, compoundYield 91%

Procedure

The title compound was prepared in accordance with the general method of Example 191(D), from 2-(chloromethyl)-4,6-difluoro-1-methyl-1H-benzo[d]imidazole (440 mg, 2.03 mmol) and trimethyl(prop-1-ynyl)silane (274 mg, 2.44 mmol). 4,6-difluoro-1-methyl-2-(4-(trimethylsilyl)but-3-ynyl)-1H-benzo[d]imidazole (539 mg, Yield: 91%) was obtained as a brown oil which can be used in the next step without any purification.

Sources & evidence

ORD record
ord-5f89cbfdd6454a348fdc43a06957e355
Source dataset
uspto-grants-2014_11
Patent number
US08883826B2

Reaction notes

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