Benzylamine → N-benzyl-2-nitroaniline

HRID 334739Notes

Reaction equation

HRID 334739 reaction equation
[C:1]1([CH2:7][NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.F[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17]>>[CH2:7]([NH:8][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 738951-Fluoro-2-nitrobenzene

Product 1

HCID 521800N-benzyl-2-nitroanilineYield 93.3%

Procedure

The title compound was prepared in accordance with the general method of Example 195(A), from phenylmethanamine (3.51 g, 32.78 mmol) and 1-fluoro-2-nitrobenzene (4.40 g, 31.22 mmol). 6.65 g of N-benzyl-2-nitrobenzenamine (Yield: 93%) was obtained as an orange crystalline solid which was used without further purification.

Sources & evidence

ORD record
ord-5d9faa7f04b04191a8f5694fb368be08
Source dataset
uspto-grants-2014_11
Patent number
US08883826B2

Reaction notes

Loading…