4-Iodo-2-methyl-1,3-thiazole → 2-Chlorophenyl 5-(2-methylthiazol-4-yl)pent-4-ynoate

HRID 334800Notes

Reaction equation

HRID 334800 reaction equation
[C:1]([O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[Cl:14])(=[O:6])[CH2:2][CH2:3][C:4]#[CH:5].I[C:16]1[N:17]=[C:18]([CH3:21])[S:19][CH:20]=1>>[CH3:21][C:18]1[S:19][CH:20]=[C:16]([C:5]#[C:4][CH2:3][CH2:2][C:1]([O:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:14])=[O:6])[N:17]=1

Participants

3

Reactant 2

HCID 537067904-Iodo-2-methyl-1,3-thiazoleHCID 860868272-Chlorophenyl pent-4-ynoate2×

Product 1

HCID 665981742-Chlorophenyl 5-(2-methylthiazol-4-yl)pent-4-ynoateYield 34%

Procedure

According to the protocol described in Example 237(B), the reaction between 2-chlorophenyl pent-4-ynoate (compound 160(A), 290 mg, 1.40 mmol) and 4-iodo-2-methylthiazole (315 mg, 1.40 mmol) afforded 145 mg of 2-chlorophenyl 5-(2-methylthiazol-4-yl)pent-4-ynoate (Yield: 34%) as yellow-oil.

Sources & evidence

ORD record
ord-74ae7f9d9eed4684b27e288a3516ecef
Source dataset
uspto-grants-2014_11
Patent number
US08883826B2

Reaction notes

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