HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodo-2-methyl-1,3-thiazole → 2-Chlorophenyl 5-(2-methylthiazol-4-yl)pent-4-ynoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodo-2-methyl-1,3-thiazole | HCID 53706790 | — |
| Reactant | 2-Chlorophenyl pent-4-ynoate | HCID 86086827 | — |
| Product | 2-Chlorophenyl 5-(2-methylthiazol-4-yl)pent-4-ynoate | HCID 66598174 | 34% |
Reaction Steps
According to the protocol described in Example 237(B), the reaction between 2-chlorophenyl pent-4-ynoate (compound 160(A), 290 mg, 1.40 mmol) and 4-iodo-2-methylthiazole (315 mg, 1.40 mmol) afforded 145 mg of 2-chlorophenyl 5-(2-methylthiazol-4-yl)pent-4-ynoate (Yield: 34%) as yellow-oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883826B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-74ae7f9d9eed4684b27e288a3516ecef |
| Source note | uspto-grants-2014_11 |