反应详情

温度

80 °C

2-(2H-Benzotriazol-2-yl)-6-chloromethyl-4-methyl-phenol (1.0 g, 3.2 mmol) is partly solved in dioxane (19 g) at 80° C. and 1-hexanol (6.6 g, 65 mmol) and sodium hydride (0.2 g, 4.3 mmol, 60% in mineral oil) are added subsequently. The orange reaction mixture is stirred at 80° C. for 2 hours and evaporated to dryness. The residue is dissolved in ethyl acetate and extracted with aqueous citric acid (5%) and brine. The organic layer is dried over sodium sulphate, filtered and evaporated to dryness. The crude product is purified by column chromatography (ethyl acetate/heptane 1:30) to yield 940 mg of 2-(2H-Benzotriazol-2-yl)-6-hexyloxymethyl-4-methyl-phenol.

1. customevaporated to dryness
2. dissolutionThe residue is dissolved in ethyl acetate
3. extractionextracted with aqueous citric acid (5%) and brine
4. dry with materialThe organic layer is dried over sodium sulphate
5. filtrationfiltered
6. customevaporated to dryness
7. customThe crude product is purified by column chromatography (ethyl acetate/heptane 1:30)