反应详情

7.67 g (67.0 mmol) methanesulfonyl chloride were given at 0° C. to a solution of 10.0 g (60.9 mmol) (4-allyloxy-phenyl)-methanol and 9.34 ml (67.0 mmol) triethylamine in 35 ml dichloromethane and stirred at room temperature (r.t.) overnight. The mixture was poured in ice water, extracted with dichloromethane and the organic phase dried over Na2SO4. After removal of solvents the residue was purified by chromatography on silica gel (ethyl acetate/n-heptane 1:5) to yield 3.12 g (28%) pale yellow oil.

1. extractionextracted with dichloromethane
2. dry with materialthe organic phase dried over Na2SO4
3. customAfter removal of solvents the residue
4. customwas purified by chromatography on silica gel (ethyl acetate/n-heptane 1:5)
5. customto yield 3.12 g (28%)