化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 1-Allyloxy-4-chloromethyl-benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | (4-(Prop-2-en-1-yloxy)phenyl)methanol | HCID 11744970 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Allyloxy-4-chloromethyl-benzene | HCID 12347936 | — |
反応手順
7.67 g (67.0 mmol) methanesulfonyl chloride were given at 0° C. to a solution of 10.0 g (60.9 mmol) (4-allyloxy-phenyl)-methanol and 9.34 ml (67.0 mmol) triethylamine in 35 ml dichloromethane and stirred at room temperature (r.t.) overnight. The mixture was poured in ice water, extracted with dichloromethane and the organic phase dried over Na2SO4. After removal of solvents the residue was purified by chromatography on silica gel (ethyl acetate/n-heptane 1:5) to yield 3.12 g (28%) pale yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07429605B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-1f1e5fa246a5440a9083e1152278fdbf |
| 出典メモ | uspto-grants-2008_09 |