反应详情

To a mixture of 2,4-bis-benzyloxy-5-bromo-benzoic acid benzyl ester (42.9 g, 85.7 mmol), potassium isopropenyl trifluoroborate (14.0 g, 95.2 mmol) and caesium carbonate (83.8 g, 257.1 mmol) in THF (800 mL) was added Pd(PPh3)4 (2.0 g) followed by water (150 mL). The mixture was heated at reflux for 72 h then allowed to cool to ambient. The mixture was reduced in vacuo to remove THF and then partitioned between water (500 mL) and EtOAc (300 mL). The organic portion was washed with brine, dried (MgSO4), filtered and reduced in vacuo to give the title compound (40.9 g) as a brown oil.

1. temperatureThe mixture was heated
2. temperatureat reflux for 72 h
3. temperatureto cool
4. customto remove THF
5. custompartitioned between water (500 mL) and EtOAc (300 mL)
6. washThe organic portion was washed with brine
7. dry with materialdried (MgSO4)
8. filtrationfiltered