Pyridinium chloride → HCID 178526884, compound

HRID 334999Notes

Reaction equation

HRID 334999 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][C:7]2[N:12]=[C:11]([O:13]C)[C:10]([N+:15]([O-:17])=[O:16])=[C:9]([O:18]C)[N:8]=2)=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1>O>[F:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][C:7]2[N:8]=[C:9]([OH:18])[C:10]([N+:15]([O-:17])=[O:16])=[C:11]([OH:13])[N:12]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 576951302-(4-Fluoro-benzyl)-4,6-dimethoxy-5-nitro-pyrimidine

Product 1

HCID 178526884HCID 178526884, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

(27) A mixture of compound (26) (1.0 g, 3.4 mmol) and pyridine hydrochloride (3.9 g, 34 mmol) was heated to 140 C for 1 hour. After it cooled to room temperature, the resultant was diluted with water. The product was collected on a filter and dried in vacuo. 2-(4-Fluoro-benzyl)-5-nitro-pyrimidine-4,6-diol (27) was obtained in a yield of 62% (1.1 g). 1H NMR (DMSO-d6)

Workup

  1. temperaturewas heated to 140 C for 1 hour
  2. customThe product was collected on
  3. filtrationa filter
  4. customdried in vacuo

Sources & evidence

ORD record
ord-887018e89de0415fb01e0cfa0c481884
Source dataset
uspto-grants-2014_11
Patent number
US08883833B2

Reaction notes

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