反应详情

温度

0 °C

1-Acetyl-N-methoxy-N-methylpiperidine-4-carboxamide (59.10 g, 276 mmol) was dissolved in THF (800 mL) and cooled to 0° C. Methylmagnesium bromide (110.3 mL, 331 mmol) (3.0M in diethyl ether) was added slowly and the resulting white slurry was agitated for 1 hour. The reaction was quenched with 300 mL of 2M HCl and the solvent was evaporated. The resulting aqueous slurry was filtered and the solids were washed with water and small amount of ether to provide the title compound (38.4 g, 82.2% yield).

1. customThe reaction was quenched with 300 mL of 2M HCl
2. customthe solvent was evaporated
3. filtrationThe resulting aqueous slurry was filtered
4. washthe solids were washed with water and small amount of ether