HRID335273

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID3283

Diethyl Ether

C4H10O

结构：CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4cc(-c5cnn(C)c5)ccn34)c2)CC1

HCID71283574

未命名化合物

PRODUCTS

生成物

结构：CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4cc(-c5cnn(C)c5)ccn34)c2)CC1.Cl

HCID71283573

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

N-(2-Fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)-7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (step 1) (30 mg, 0.053 mmol) in MeOH (2 ml) was treated with HCl in ether (0.053 ml, 0.053 mmol) and the solution was evaporated to dryness and dried in vacuo overnight to afford the title compound; LC-MS: Rt 0.82 mins; MS m/z 56, [M+H]+; Method 2minLC_v003

WORKUP

后处理

customthe solution was evaporated to dryness
customdried in vacuo overnight

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-573141bdfa3a46c8acb57a6be854b3f4
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08883819B2
来源说明: uspto-grants-2014_11

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:24])[NH:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)=[CH:4][C:3]=1[NH:25][C:26]([C:28]1[N:32]2[CH:33]=[CH:34][C:35]([C:37]3[CH:38]=[N:39][N:40]([CH3:42])[CH:41]=3)=[CH:36][C:31]2=[N:30][CH:29]=1)=[O:27].[ClH:43].CCOCC>CO>[ClH:43].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:24])[NH:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N:17]2[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]2)=[CH:4][C:3]=1[NH:25][C:26]([C:28]1[N:32]2[CH:33]=[CH:34][C:35]([C:37]3[CH:38]=[N:39][N:40]([CH3:42])[CH:41]=3)=[CH:36][C:31]2=[N:30][CH:29]=1)=[O:27]