2-Amino-2-methyl-1-propanol → HCID 71283036, compound

HRID 335295Notes

Reaction equation

HRID 335295 reaction equation
[CH3:1][C:2]1([CH3:41])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][NH:9][C:10]([C:12]1[CH:13]=[CH:14][C:15]([F:40])=[C:16]([NH:18][C:19]([C:21]2[N:25]3[CH:26]=[CH:27][C:28]([C:30]4[CH:38]=[CH:37][C:33]([C:34]([OH:36])=O)=[C:32]([F:39])[CH:31]=4)=[CH:29][C:24]3=[N:23][CH:22]=2)=[O:20])[CH:17]=1)=[O:11].[NH2:42][C:43]([CH3:47])([CH3:46])[CH2:44][OH:45]>>[CH3:1][C:2]1([CH3:41])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][NH:9][C:10]([C:12]1[CH:13]=[CH:14][C:15]([F:40])=[C:16]([NH:18][C:19]([C:21]2[N:25]3[CH:26]=[CH:27][C:28]([C:30]4[CH:38]=[CH:37][C:33]([C:34](=[O:36])[NH:42][C:43]([CH3:47])([CH3:46])[CH2:44][OH:45])=[C:32]([F:39])[CH:31]=4)=[CH:29][C:24]3=[N:23][CH:22]=2)=[O:20])[CH:17]=1)=[O:11]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 71283788HCID 71283788, compound

Product 1

HCID 71283036HCID 71283036, compound

Procedure

The title compound was prepared analogously to Example 7.4 from 4-(3-(5-(2-(2,2-dimethylpyrrolidin-1-yl)ethylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoic acid (step 3) and 2-amino-2-methylpropan-1-ol;

Sources & evidence

ORD record
ord-f04e37b5cc404f018764e9b6508bcf6e
Source dataset
uspto-grants-2014_11
Patent number
US08883819B2

Reaction notes

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