HRID335299

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11807

2-Amino-2-methylpropan-1-ol

C4H11NO

结构：C[C@@H]1CCC[C@H](C)N1CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(-c4ccc(C(=O)O)c(F)c4)ccn23)c1

HCID71283338

未命名化合物

PRODUCTS

生成物

结构：C[C@@H]1CCC[C@H](C)N1CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(-c4ccc(C(=O)NC(C)(C)CO)c(F)c4)ccn23)c1

HCID71283046

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 4-(3-(5-(2-(2,6-cis-dimethylpiperidin-1-yl)ethylcarbamoyl)-2-fluorophenyl carbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoic acid (step 1) and 2-amino-2-methylpropan-1-ol analogously to Example 8.1, step 2;

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c46a0cb45347413aaacd7607c1e2cd78
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08883819B2
来源说明: uspto-grants-2014_11

反应 SMILES

[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[N:3]1[CH2:9][CH2:10][NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]([F:42])=[C:18]([NH:20][C:21]([C:23]2[N:27]3[CH:28]=[CH:29][C:30]([C:32]4[CH:40]=[CH:39][C:35]([C:36](O)=[O:37])=[C:34]([F:41])[CH:33]=4)=[CH:31][C:26]3=[N:25][CH:24]=2)=[O:22])[CH:19]=1)=[O:13].[NH2:43][C:44]([CH3:48])([CH3:47])[CH2:45][OH:46]>>[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[N:3]1[CH2:9][CH2:10][NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]([F:42])=[C:18]([NH:20][C:21]([C:23]2[N:27]3[CH:28]=[CH:29][C:30]([C:32]4[CH:40]=[CH:39][C:35]([C:36](=[O:37])[NH:43][C:44]([CH3:48])([CH3:47])[CH2:45][OH:46])=[C:34]([F:41])[CH:33]=4)=[CH:31][C:26]3=[N:25][CH:24]=2)=[O:22])[CH:19]=1)=[O:13]