Hydrochloric Acid → HCID 71282942, compound

HRID 335334Notes

Reaction equation

HRID 335334 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6].[N:13]1[CH:14]=[C:15]([C:22](Cl)=[O:23])[N:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=12.Cl.O>N1C=CC=CC=1>[F:12][C:11]1[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=1[NH:1][C:22]([C:15]1[N:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]2=[N:13][CH:14]=1)=[O:23]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 12541234Methyl 3-amino-4-fluorobenzoateHCID 74890117Imidazo[1,2-a]pyridine-3-carbonyl Chloride

Product 1

HCID 71282942HCID 71282942, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of methyl 3-amino-4-fluorobenzoate (5 g, 29.6 mmol) in pyridine (200 ml) was treated with imidazo[1,2-a]pyridine-3-carbonyl chloride.HCl (step 1) (6.43 g, 29.6 mmol) and the mixture was stirred at RT for 2 days. The mixture was poured into water (30 ml) and a small exotherm was observed. After cooling to RT, the resulting precipitate was filtered and dried in a vacuum oven to afford the title compound;

Workup

  1. filtrationthe resulting precipitate was filtered
  2. customdried in a vacuum oven

Sources & evidence

ORD record
ord-5fe7a163af0d4b23bca0bf7d66c6c8c5
Source dataset
uspto-grants-2014_11
Patent number
US08883819B2

Reaction notes

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