HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-2-(2-(Methoxymethyl)pyrrolidin-1-yl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-tert-Butyl 2-(2-(methoxymethyl)pyrrolidin-1-yl)ethylcarbamate | HCID 71283522 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-2-(2-(Methoxymethyl)pyrrolidin-1-yl)ethanamine | HCID 57639942 | — |
Reaction Steps
A solution of (S)-tert-butyl 2-(2-(methoxymethyl)pyrrolidin-1-yl)ethylcarbamate (step 1) (1.89 g, 7.32 mmol) and in MeOH (5 ml) and treated with 2M HCl in MeOH (10 equivalents) at room temperature over the weekend. The solvent was removed in vacuo to afford the title compound;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883819B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-1c802c2680ba4f128f90f4fbd50fe2b7 |
| Source note | uspto-grants-2014_11 |