Hydrochloric Acid → (S)-2-(2-(Methoxymethyl)pyrrolidin-1-yl)ethanamine

HRID 335337Notes

Reaction equation

HRID 335337 reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C.Cl>CO>[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[CH2:9][CH2:10][NH2:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71283522(S)-tert-Butyl 2-(2-(methoxymethyl)pyrrolidin-1-yl)ethylcarbamate

Product 1

HCID 57639942(S)-2-(2-(Methoxymethyl)pyrrolidin-1-yl)ethanamine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of (S)-tert-butyl 2-(2-(methoxymethyl)pyrrolidin-1-yl)ethylcarbamate (step 1) (1.89 g, 7.32 mmol) and in MeOH (5 ml) and treated with 2M HCl in MeOH (10 equivalents) at room temperature over the weekend. The solvent was removed in vacuo to afford the title compound;

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-1c802c2680ba4f128f90f4fbd50fe2b7
Source dataset
uspto-grants-2014_11
Patent number
US08883819B2

Reaction notes

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