反应详情

温度

0 °C

271 mg (0.165 ml, 2.28 mmol) thionyl chloride were added drop by drop at 0° C. to a solution of 0.2 ml N,N-dimethylformamide (DMF) and 250 mg (1.14 mmol) [5-(3-Chloro-phenyl)-pyridin-3-yl]-methanol in 20 ml dichloromethane and stirred for 3 h at 0° C. The mixture was poured on ice/sodium bicarbonate solution and the organic phase separated. The water phase was extracted with dichloromethane. The combined organic phases were washed with water, dried (sodium sulphate), evaporated and the obtained material (248 mg, 84%) used without further purification.

1. additionThe mixture was poured on ice/sodium bicarbonate solution
2. customthe organic phase separated
3. extractionThe water phase was extracted with dichloromethane
4. washThe combined organic phases were washed with water
5. dry with materialdried (sodium sulphate)
6. customevaporated
7. customthe obtained material (248 mg, 84%) used without further purification