5-Amino-2-naphthol → HCID 178515717, compound

HRID 33550Notes

Reaction equation

HRID 33550 reaction equation
[Br:1][C:2]1[C:7]2[NH:8][C:9](Cl)=[N:10][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.[NH2:16][C:17]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:18]=1[CH:19]=[CH:20][C:21]([OH:27])=[CH:22]2>>[Br:1][C:2]1[C:7]2[NH:8][C:9]([NH:16][C:17]3[CH:26]=[CH:25][CH:24]=[C:23]4[C:18]=3[CH:19]=[CH:20][C:21]([OH:27])=[CH:22]4)=[N:10][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1

Participants

3

Reactant 2

HCID 68655-Amino-2-naphtholHCID 178506061HCID 178506061, compound

Product 1

HCID 178515717HCID 178515717, compoundYield 57%

Procedure

The reaction of 7-bromo-2-chloro-5-(trifluoromethyl)-1H-benzo[d]imidazole (240 mg, 0.8 mmol, prepared according to the procedure described in WO 2004/035549 A1) with 5-amino-2-naphthol (64 mg, 0.4 mmol, TCI-US) under the condition of Example 2 afforded the title compound (57%) as an amorphous solid. MS (ESI, pos. ion) m/z: 423 (M+1).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-c434a74d61304545bd72626243051fec
Source dataset
uspto-grants-2008_09
Patent number
US07429608B2

Reaction notes

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