Phosphorus oxychloride → HCID 50914394, compound

HRID 335651Notes

Reaction equation

HRID 335651 reaction equation
[CH3:1][C:2]1([CH3:15])[O:6][C@@H:5]([CH2:7][C:8]2([S:11]([O-])(=[O:13])=[O:12])[CH2:10][CH2:9]2)[CH2:4][O:3]1.[Na+].P(Cl)(Cl)([Cl:19])=O>>[CH3:1][C:2]1([CH3:15])[O:6][C@@H:5]([CH2:7][C:8]2([S:11]([Cl:19])(=[O:13])=[O:12])[CH2:10][CH2:9]2)[CH2:4][O:3]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 86698215HCID 86698215, compound

Product 1

HCID 50914394HCID 50914394, compound

Procedure

A solution of sodium (S)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonate (1 eq) and phosphoryl trichloride (POCl3, 0.7 mL/mmol) is heated at 80° C. for 1 hour. The reaction mixture is cooled to room temperature, poured onto ice, stirred for 30 minutes and extracted with chloroform (2×). The combined organic extracts are dried (MgSO4) and concentrated under reduced pressure.

Workup

  1. additionpoured onto ice
  2. extractionextracted with chloroform (2×)
  3. dry with materialThe combined organic extracts are dried (MgSO4)
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-dd96387118e541c6a5688cdabab2f899
Source dataset
uspto-grants-2014_11
Patent number
US08884058B2

Reaction notes

Loading…