HRID335891
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 85 °C
PROCEDURE
实验过程
Sodium carbonate (saturated, 1 mL), Pd(PPh3)4 (23.52 mg, 0.020 mmol), (S)-4′-fluoro-7′-(2-fluoropyridin-3-yl)-2′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5H-spiro[oxazole-4,9′-xanthen]-2-amine (200 mg, 0.407 mmol), and 3-bromo-6-methylpyridazine (141 mg, 0.814 mmol) were combined in DMF (5 mL). The solution was heated at 85° C. overnight. The solution was filtered through celite and the derived residue was purified via Gilson HPLC (gradient elution 25-65% MeCN/H2O, 0.1% TFA) to afford (S)-4′-fluoro-7′-(2-fluoropyridin-3-yl)-2′-(6-methylpyridazin-3-yl)-5H-spiro[oxazole-4,9′-xanthen]-2-amine as an off white solid. MS m/z=458.0 [M+H].
WORKUP
后处理
- filtrationThe solution was filtered through celite
- customthe derived residue was purified via Gilson HPLC (gradient elution 25-65% MeCN/H2O, 0.1% TFA)