反应详情

温度

60 °C

A 3 neck 22 L RBF equipped with a mechanical stirrer, temperature probe and N2 inlet was charged with concentrated H2SO4 (2.7 L) and heated to 60° C. To this mixture was added 2-(4-bromophenoxy)-4-fluoro-5-methoxybenzoic acid (1.3 kg, 3.81 mol) in portions such that the internal temp remained below 70° C. The resulting mixture was stirred at 60° C. for 1 hour at which point the reaction mixture was cooled to 0° C. and slowly poured onto ice water. The resulting solids were removed by filtration, washed with water and triturated with EtOAc (3 L). The solid was then washed with EtOAc, hexane and dried under vacuum at 30° C. to afford 7-bromo-3-fluoro-2-methoxy-9H-xanthen-9-one as an off white solid.

1. customA 3 neck 22 L RBF equipped with a mechanical stirrer
2. customremained below 70° C
3. temperaturewas cooled to 0° C.
4. additionslowly poured onto ice water
5. customThe resulting solids were removed by filtration
6. washwashed with water
7. customtriturated with EtOAc (3 L)
8. washThe solid was then washed with EtOAc, hexane
9. customdried under vacuum at 30° C.