反应详情

To a solution of 3-methoxy-5-(5-methyl-isoxazol-3-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone (120 mg) in acetone (1 ml) in a microwave vial is added 2N HCl (0.6 ml) and the resultant solution is heated to 130° C. by microwave irradiation, with stirring, for 30 minutes. The solvent is removed under reduced pressure, and the residue triturated with hexane to give a white solid, which is filtered and washed well with hexane to give 4-(5-methyl-isoxazol-3-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione.

1. customThe solvent is removed under reduced pressure
2. customthe residue triturated with hexane
3. customto give a white solid, which
4. filtrationis filtered
5. washwashed well with hexane