反应详情

To a solution of 4-[1-furan-3-yl-meth-(E)-ylidene]-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione (50 mg) in dichloromethane (2 ml) is added triethylamine (118 μl), followed by trimethylacetyl chloride (105 μl) and the resulting suspension allowed to stir at room temperature for 3 hours. The crude reaction mixture is then purified by automated flash chromatography to give 2,2-dimethyl-propionic acid 4-[1-furan-3-yl-meth-(E)-ylidene]-3-oxo-2-(2,4,6-trimethyl-phenyl)-cyclopent-1-enyl ester.

1. customThe crude reaction mixture
2. customis then purified by automated flash chromatography