反应详情

温度

80 °C

Sodium azide (361 mg) was added to a solution of 4-amino-5-(quinolin-3-yl)-6,7,8,9-tetrahydropyrimido[5,4-b]indolizin-8-yl methanesulfonate (758 mg) obtained in Step 9 in DMF (9 ml) at room temperature, and the mixture was stirred at 80° C. for 4 hours. After cooling, the reaction mixture was poured into water, followed by extraction with ethyl acetate. The organic layer was washed with water and a saturated sodium chloride solution, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound as a yellow solid (508 mg).

1. temperatureAfter cooling
2. extractionfollowed by extraction with ethyl acetate
3. washThe organic layer was washed with water
4. dry with materiala saturated sodium chloride solution, and dried over anhydrous sodium sulfate
5. distillationThe solvent was distilled off under reduced pressure