反应详情

Hydroxylamine (Fluka 55458; 50% in water; 11.28 mL; 187.76 mmol; 5 eq.) was added to a solution of 2-methoxybenzonitrile (Alrich 231231; 4.59 mL; 37.55 mmol; 1 eq.) in EtOH (50 mL) and the resulting mixture was stirred at room temperature for 16 hours then at 55° C. for 24 hours. The solvent was then evaporated and the resulting colourless oil was further dried under high vacuum to give a white solid. The latter was triturated in n-hexane, filtered and dried to afford the title compound (6.29 g, quantitative) as a white solid.

1. waitat 55° C. for 24 hours
2. customThe solvent was then evaporated
3. customthe resulting colourless oil was further dried under high vacuum
4. customto give a white solid
5. customThe latter was triturated in n-hexane
6. filtrationfiltered
7. customdried